My thoughts are that on light stock it wont hurt anything, but winding up the impression on a heavy board could possibly hurt the cylinder bearings and put a lot of pressure on the driveline, leading to premature wear in gears etc...but thats pretty extreme.. I remember watchin an older printer trying to run 300gsm board on about .05 setting as he didnt want to replace a damamged blanket. The press was nearly stopping with each revolution and the dots were a mess lol..
I am not a press engineer... so i could be really very wrong too
Just get on with it. Its as simple as that.